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. 2004 Jun;16(6):1358-64.
doi: 10.1105/tpc.160630.

Paramutation: the chromatin connection

Chris B Della Vedova  1 , Karen C Cone
Affiliations

Paramutation: the chromatin connection

Chris B Della Vedova et al. Plant Cell. 2004 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
Four Examples of Paramutation. In each panel, actively expressed alleles are shown in black, and silenced alleles are shown in gray. Phenotypes are listed below each genotype. (A) In maize, the paramutable B-I allele is silenced by the paramutagenic B′ allele in the first generation. In the next generation, the newly silenced B-I allele is paramutagenic and silences a naive B-I allele. (B) In maize, the paramutable R-r:standard allele is expressed in the first generation when heterozygous with the paramutagenic R-stippled. When the heterozygote is crossed to a plant homozygous for a neutral r allele, R-r:standard is silenced in the second generation progeny. (C) In mouse, the chimeric Rasgrf1tm3.1Pds allele, when crossed as male, activates maternal expression of the normally paternally expressed Rasgrf1 allele, resulting in biallelic expression in the first generation. Maternal expression of Rasgrf1 is maintained when the chimeric allele is segregated away in the second generation. (D) In Arabidopsis autotetraploids, cross of hygromycin-resistant plants (RRRR) with hygromycin-sensitive plants (SSSS) carrying a silent transgene produces first generation progeny that are hygromycin resistant. Self-fertilization of the hybrids produces mainly hygromycin-sensitive (silenced) progeny.
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