Review
doi: 10.2174/1389557043403837.
The structure of ribosome inactivating proteins
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- PMID: 15180504
- DOI: 10.2174/1389557043403837
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Review
The structure of ribosome inactivating proteins
Mini Rev Med Chem.
2004 Jun.
Abstract
Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.
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