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Review
. 2004 Jun;11(3):271-9.
doi: 10.2174/0929866043407084.

Alpha-synuclein aggregation

Angela M Bodles  1 , G Brent Irvine
Affiliations
Review

Alpha-synuclein aggregation

Angela M Bodles et al. Protein Pept Lett. 2004 Jun.

Abstract

Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

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