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Review
. 2004 Jul;79(1):3-9.
doi: 10.1016/j.exer.2004.03.014.

Molecular genetics of age-related cataract

J Fielding Hejtmancik  1 , Marc Kantorow
Affiliations
Review

Molecular genetics of age-related cataract

J Fielding Hejtmancik et al. Exp Eye Res. 2004 Jul.

Abstract

Advances in molecular biological and genetic technology have greatly accelerated elucidation of the genetic contribution to age-related cataract. Epidemiological studies have documented tendencies for cataracts to occur more frequently in relatives of cataract patients than in the general population, genetic studies have demonstrated contributory roles of some specific genes in age related cataract in small populations, and molecular studies have shown changes in expression of specific genes in cataractous lenses. Together, these studies are beginning to provide a conceptual framework for understanding age-related cataracts.

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References

    1. Familial aggregation of lens opacities. The Framingham Eye Study and the Framingham Offspring Eye Study. Am J Epidemiol. 1994a;140:555–564. - PubMed
    1. Incidence and progression of cortical, nuclear, and posterior subcapsular cataracts. The Italian-American Cataract Study Group. Am J Ophthalmol. 1994b;118:623–631. - PubMed
    1. Alberti G, Oguni M, Podgor M, Sperduto RD, Tomarev S, Grassi C, Williams S, Kaiser-Kupfer M, Maraini G, Hejtmancik JF. Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Invest Ophthalmol Vis Sci. 1996;37:1167–1173. - PubMed
    1. Bassnett S, Kuszak JR, Reinish L, Brown HG, Beebe DC. Intercellular communication between epithelial and fiber cells of the eye lens. J Cell Sci. 1994;107:799–811. - PubMed
    1. Beaumont C, Leneuve P, Devaux I, Scoazec JY, Berthier M, Loiseau MN, Grandchamp B, Bonneau D. Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract. Nat Genet. 1995;11:444–446. - PubMed

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