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. 2004 Jun 8;62(11):1996-8.
doi: 10.1212/01.wnl.0000129275.13169.be.

Influence of the amyloid precursor protein locus on dementia in Down syndrome

M Margallo-Lana  1 , C M Morris, A M Gibson, A L Tan, D W K Kay, S P Tyrer, B P Moore, C G Ballard
Affiliations

Influence of the amyloid precursor protein locus on dementia in Down syndrome

M Margallo-Lana et al. Neurology. .

Abstract

Background: The amyloid precursor protein (APP) locus on chromosome 21 influences the development of Alzheimer disease.

Method: The authors investigated the relationship between a tetranucleotide repeat on intron 7 of the APP gene and the age at onset of dementia in Down syndrome (DS).

Results: There was a 13-year difference in the age at onset of dementia in DS associated with the number of tetranucleotide repeat alleles in APP.

Conclusion: APP is an important locus predicting the age at onset of dementia in people with Down syndrome.

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