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Clinical Trial
. 2004 May;20(5):493-6.
doi: 10.1089/088922204323087732.

Haemophilus influenzae type b immunization in adults infected with the human immunodeficiency virus

Sigrid De Sousa dos Santos  1 , Marta Heloísa Lopes, Vera Simonsen, Hélio Hehl Caiaffa Filho
Affiliations
Clinical Trial

Haemophilus influenzae type b immunization in adults infected with the human immunodeficiency virus

Sigrid De Sousa dos Santos et al. AIDS Res Hum Retroviruses. 2004 May.

Abstract

The purpose of this study was to assess the influence of Haemophilus influenzae type b conjugate vaccine on HIV-1 RNA level, CD4 count, and anti-Hib polysaccharide (PRP) antibody concentration. Eighty HIV-infected adults were randomized to receive Hib conjugate vaccine or not. Twenty HIV-seronegative controls were also vaccinated. Blood samples were taken before and after vaccination, with a follow-up period of 6 months. HIV infection markers and anti-PRP antibodies were monitored. There was no change in either HIV-1 viremia or CD4 count after vaccination. Immunization immunogenicity was superior in HIV-uninfected than in HIV-infected individuals (p < 0.01). Hib vaccination was safe but induced suboptimal antibody response in HIV-infected adults.

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