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. 2004 Jul 19;91(2):355-8.
doi: 10.1038/sj.bjc.6601894.

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

S Bamford  1 , E Dawson, S Forbes, J Clements, R Pettett, A Dogan, A Flanagan, J Teague, P A Futreal, M R Stratton, R Wooster
Affiliations

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

S Bamford et al. Br J Cancer. .

Abstract

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

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Figures

Figure 1
Figure 1
The initial output from COSMIC is a graphical view of the mutations distributed along the linear amino-acid sequence of the gene. The scale bar incorporates a zoom function to generate a more detailed view of the protein to the point where individual amino acids are named (when there are fewer than 31 amino acids displayed). When a Pfam or Interpro domain is present, a link is provided to these resources (adjacent to the Domain label) while links to the papers that were curated are positioned beneath the mutations (in red) with an option of either viewing the papers that have data for a particular location in the protein or all of the papers for the selected gene.
See this image and copyright information in PMC

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