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. 2004 Jun;20(6):757-67.
doi: 10.1016/j.immuni.2004.05.008.

NKG2D blockade prevents autoimmune diabetes in NOD mice

Kouetsu Ogasawara  1 , Jessica A Hamerman, Lauren R Ehrlich, Helene Bour-Jordan, Pere Santamaria, Jeffrey A Bluestone, Lewis L Lanier
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Free article

NKG2D blockade prevents autoimmune diabetes in NOD mice

Kouetsu Ogasawara et al. Immunity. 2004 Jun.
Free article

Abstract

NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8(+) T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.

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