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. 2004 Jun 23;22(19):2489-93.
doi: 10.1016/j.vaccine.2003.11.073.

Enhancement of DNA vaccine potency in rhesus macaques by electroporation

Gillis Otten  1 , Mary Schaefer, Barbara Doe, Hong Liu, Indresh Srivastava, Jan zur Megede, Derek O'Hagan, John Donnelly, Georg Widera, Dietmar Rabussay, Mark G Lewis, Susan Barnett, Jeffrey B Ulmer
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Enhancement of DNA vaccine potency in rhesus macaques by electroporation

Gillis Otten et al. Vaccine. .

Abstract

The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals.

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