Review
doi: 10.1016/j.ceb.2004.02.003.
Endocytosis and cancer
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- PMID: 15196558
- DOI: 10.1016/j.ceb.2004.02.003
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Review
Endocytosis and cancer
Curr Opin Cell Biol.
2004 Apr.
Abstract
Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.
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