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. 2004 Jul;63(1):61-4.
doi: 10.1016/j.antiviral.2004.02.002.

Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue

Deborah J Bidanset  1 , Rachel J Rybak, Caroll B Hartline, Earl R Kern
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Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue

Deborah J Bidanset et al. Antiviral Res. 2004 Jul.

Abstract

For immunocompromised hosts, human cytomegalovirus (CMV) can be a serious problem. For evaluation of antivirals used to treat CMV retinitis, we have used severe combined immunodeficient mice as hosts for human retinal tissue implanted in the eye and subsequently infected with CMV. Treatment with ganciclovir or cidofovir resulted in a significant suppression of CMV replication.

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