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. 2004 Jun 18;568(1-3):79-82.
doi: 10.1016/j.febslet.2004.04.095.

Ipaf is upregulated by tumor necrosis factor-alpha in human leukemia cells

Olga Gutierrez  1 , Carlos Pipaon, Jose L Fernandez-Luna
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Free article

Ipaf is upregulated by tumor necrosis factor-alpha in human leukemia cells

Olga Gutierrez et al. FEBS Lett. .
Free article

Abstract

Ipaf has been associated with apoptosis, cytokine processing, and nuclear factor-kappaB activation. Here, we describe that Ipaf is highly expressed in myelomonocytic cells and that the mRNA levels of Ipaf progressively increase during differentiation of CD34(+) progenitors to granulocytes and monocytes. Additionally, treatment with tumor necrosis factor-alpha and exposure to UV radiation induced the transcriptional activation of Ipaf in human leukemia HL-60 cells. Thus, Ipaf may contribute to modulate the response of myeloid cells to genotoxic and pro-inflammatory stimuli.

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