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. 2004 Jul;126(1):81-4.
doi: 10.1111/j.1365-2141.2004.04999.x.

Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells

Kennosuke Karube  1 , Koichi Ohshima, Takeshi Tsuchiya, Takahiro Yamaguchi, Riko Kawano, Junji Suzumiya, Atae Utsunomiya, Mine Harada, Masahiro Kikuchi
Affiliations

Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells

Kennosuke Karube et al. Br J Haematol. 2004 Jul.

Abstract

Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.

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