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Review
. 2004 Jun 22;101(25):9175-6.
doi: 10.1073/pnas.0403722101. Epub 2004 Jun 15.

Linear ordering and dynamic segregation of the bacterial chromosome

Adam M Breier  1 , Nicholas R Cozzarelli
Affiliations
Review

Linear ordering and dynamic segregation of the bacterial chromosome

Adam M Breier et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Organization and replication dynamics of the Caulobacter chromosome. Color indicates distance from the origin along the length of the chromosome; the order is red, orange, yellow, green, blue, and purple. O and T indicate the origin and terminus of replication. The flagellum and pili are shown as curved and slanted black lines, respectively, and the cell stalk is represented by two vertical black segments. (A1) In the G1 phase, the replication origin and nearby sequences (red) are close to the flagellar pole of the cell. (A2) After initiation, one copy of the origin moves to the other end of the cell and the other moves a little closer to the flagellar pole. (A3) As regions increasingly distant from the origin are copied, they too are segregated. (A4) After division, the chromosomes in each daughter cell are positioned as they were in the parent before replication. (B) The chromosome must adopt a folded conformation to fit within the cell volume. (B 1 and 2) Depicted is a series of stacked loops orthogonal to the cell axis; either model is consistent with the data of Viollier et al. (7). The two schemes differ as to whether the left and right halves of the chromosome occupy the same region (B1) or are kept apart (B2). Other possible organizations—a rosette in which loops emanate in various directions (B3), a random coil (B4), and loops along the cell axis (B5)—are ruled out by the data of Viollier et al.
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