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Comment
. 2004 Jun;113(12):1681-3.
doi: 10.1172/JCI22153.

Is transplantation tolerable?

Terry B Strom  1
Affiliations
Comment

Is transplantation tolerable?

Terry B Strom. J Clin Invest. 2004 Jun.

Abstract

To test the hypothesis that chronic stimulation of T cells with a weak agonistic antigen will generate regulatory T cells and immune tolerance, a study reported in this issue employed the redesign of a minor histocompatibility antigen. Using knowledge of residues at which the antigen contacts the T cell receptor, a weak agonist was produced. Pretreatment with this altered antigen produced transplant tolerance, generation of regulatory T cells, and a loss of many antigen-reactive T cells.

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Figures

Figure 1
Figure 1
As compared with antigenic stimulation (A), stimulation of female transgenic mice with an APL of the Dby minor histocompatibility (mH) antigen, which delivers incomplete signals to naive T cells, (a) promotes the production of Foxp3+ regulatory T cells, (b) limits the development of effector T cells, and (c) magnifies the apoptotic loss of activated T cells (B), resulting in tolerance to male skin grafts. Ag, antigen.
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References

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