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Review
. 2004 Mar;35(3):229-37.
doi: 10.1016/j.ceca.2003.10.016.

Calcium-sensing receptor regulation of renal mineral ion transport

Jianming Ba  1 , Peter A Friedman
Affiliations
Review

Calcium-sensing receptor regulation of renal mineral ion transport

Jianming Ba et al. Cell Calcium. 2004 Mar.

Abstract

Extracellular calcium has long been known to affect the rate and magnitude of renal calcium and phosphate recovery. In this review, we consider some of these findings in light of our present understanding of the tubular localization of the calcium-sensing receptor (CaSR). Experiments directly implicating the CaSR in regulating calcium and phosphate transport are described. These results point to an important role of the CaSR in regulating PTH-dependent calcium absorption by cortical thick ascending limbs and on PTH-sensitive proximal tubule phosphate transport. Possible avenues for further investigation are suggested.

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