Review
doi: 10.1016/j.ceca.2003.10.019.
The role of the calcium-sensing receptor in epidermal differentiation
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- PMID: 15200150
- DOI: 10.1016/j.ceca.2003.10.019
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Review
The role of the calcium-sensing receptor in epidermal differentiation
Cell Calcium.
2004 Mar.
Free article
Abstract
Calcium regulates the proliferation and differentiation of keratinocytes both in vivo and in vitro. Elevated extracellular Ca2+ concentration ([Ca2+]o) raises the intracellular free calcium ([Ca2+]i) and activates differentiation-related genes. Cells lacking the calcium-sensing receptor (CaR) fail to respond to [Ca2+]o and to differentiate, indicating a role for CaR in keratinocyte differentiation. These concepts derived from in vitro experiments have been tested and confirmed in two mouse models.
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