doi: 10.1021/ol049267j.
A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates
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- PMID: 15200334
- DOI: 10.1021/ol049267j
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A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates
Org Lett.
.
Abstract
[reaction: see text] A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.
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