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. 2004 Jul;90(7):745-9.
doi: 10.1136/hrt.2003.019950.

Associations of components of adult height with coronary heart disease in postmenopausal women: the British women's heart and health study

D A Lawlor  1 , M Taylor, G Davey Smith, D Gunnell, S Ebrahim
Affiliations

Associations of components of adult height with coronary heart disease in postmenopausal women: the British women's heart and health study

D A Lawlor et al. Heart. 2004 Jul.

Abstract

Objective: To assess the associations between components of adult height and coronary heart disease (CHD) in postmenopausal women.

Methods: Cross sectional analysis of 4286 women randomly selected from 23 British towns. The association of components of adult height with prevalent CHD (n = 694) were assessed.

Results: Shorter stature, shorter leg length, and trunk length were all associated with CHD in age adjusted analyses. The association between trunk length and CHD was attenuated to the null with adjustment for smoking. The leg length-CHD association was independent of smoking, socioeconomic position in childhood and adulthood, birth weight, and other potential confounders. Insulin resistance did not appear to be an important mediating factor in the association between leg length and CHD. After full adjustment for all potential confounding factors the odds ratio (95% confidence interval) of CHD for a 1 SD (4.3 cm) increase in leg length was 0.84 (0.77 to 0.93) and the odds ratio for a 1 SD (0.05) increase in the leg to trunk ratio was 0.85 (0.79 to 0.95).

Conclusions: The specific association between leg length and CHD suggests that early life environmental exposures that influence skeletal growth also influence CHD risk in later life.

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References

    1. Palmer JR, Rosenberg L, Shapiro S. Stature and the risk of myocardial infarction in women. Am J Epidemiol 1990;132:27–32. - PubMed
    1. Rich-Edwards JW, Manson JE, Stampfer MJ, et al. Height and the risk of cardiovascular disease in women. Am J Epidemiol 1995;142:909–17. - PubMed
    1. Leon DA, Davey Smith G, Shipley M, et al. Adult height and mortality in London: early life, socioeconomic confounding, or shrinkage? J Epidemiol Community Health 1995;49:5–9. - PMC - PubMed
    1. Barker DJ. Early growth and cardiovascular disease. Arch Dis Child 1999;80:305–7. - PMC - PubMed
    1. Gunnell D . Can adult anthropometry be used as a biomarker for prenatal and childhood exposures? Int J Epidemiol 2002;31:390–4. - PubMed

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