New nitric oxide-donating drugs for the treatment of airway diseases

Abstract

Nitric oxide (NO) is involved in many pathological and physiological processes in mammals, providing a possible biological basis for the use of NO replacement therapy in many conditions. A series of compounds have been synthesized in which an NO-releasing group has been linked to well-established parent molecules. This strategy has resulted in novel molecules with an improved profile of pharmacological activity, either in terms of enhanced therapeutic efficacy or reduced side effects. This review examines the biological significance, mechanism(s) of action and therapeutic potential of such compounds in respiratory disease.