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. 2004 Jul 16;14(14):3743-6.
doi: 10.1016/j.bmcl.2004.04.102.

Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives

B Narasimhulu Naidu  1 , Margaret E Sorenson, Thomas Hudyma, Xiaofan Zheng, Yunhui Zhang, Joanne J Bronson, Michael J Pucci, Junius M Clark, Yasutsugu Ueda
Affiliations

Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives

B Narasimhulu Naidu et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1-12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7-9 also exhibited potent in vivo activity.

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