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. 2004 Jul 16;14(14):3825-8.
doi: 10.1016/j.bmcl.2004.04.105.

Novel dual inhibitors of calpain and lipid peroxidation

Serge Auvin  1 , Bernadette Pignol, Edith Navet, Dominique Pons, Jean-G Marin, Dennis Bigg, Pierre-E Chabrier
Affiliations

Novel dual inhibitors of calpain and lipid peroxidation

Serge Auvin et al. Bioorg Med Chem Lett. .

Abstract

A series of molecules with dual inhibitory activities on calpain and lipid peroxidation were synthesized. These hybrid compounds were built on the calpain pharmacophore 2-hydroxytetrahydrofuran linked to a set of antioxidants via a l-leucine linker. Compound 7, the most potent in cellular calpain and lipid peroxidation inhibitions, provided effective protection against glial cell death induced by maitotoxin.

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