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. 2004 Apr;13(2):93-103.
doi: 10.1080/09629350410001688486.

Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy

Marcelo Barreto Spillere da Silva  1 , Roseli Coimbra Farges, Tânia Silvia Fröde
Affiliations

Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy

Marcelo Barreto Spillere da Silva et al. Mediators Inflamm. 2004 Apr.

Abstract

Background: Studies on peripheral benzodiazepine receptor function have yielded a diverse list of activities of which the anti-inflammatory effects need to be further examined.

Aims: To evaluate the role of steroids, nitric oxide and adenosine-deaminase in the anti-inflammatory effect of PK11195.

Methods: Pleurisy was induced by intrapleural injection of carrageenan in mice pre-treated or not with PK11195. Leukocytes, exudation, adenosine-deaminase (ADA) activity and nitric oxide (NO) level were measured. Steroid involvement was evaluated by pre-treatment with D,L-aminogluthetimide before PK11195.

Results: Leukocytes, exudation and NO levels were reduced by PK11195 in the early (4 h) phase. In the late (48 h) phase, PK11195 decreased leukocytes and ADA activity. D,L-aminogluthetimide reversed the effect of PK11195 on exudate (4 h), as well as total and differential leukocytes and NO levels (48 h).

Conclusions: Steroids, NO and ADA are implicated in the anti-inflammatory action of PK11195.

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