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Review
. 2004 May-Aug;23(3-4):265-72.
doi: 10.1080/08830180490452594.

Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus: the road from anergy to autoimmunity

Ana M Blasini  1 , Martín A Rodríguez
Affiliations
Review

Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus: the road from anergy to autoimmunity

Ana M Blasini et al. Int Rev Immunol. 2004 May-Aug.

Abstract

Some of the signaling phenotypic abnormalities observed in peripheral blood T cells from patients with systemic lupus erythematosus resemble those seen in cells anergized by stimulation through the TCR/CD3 complex, in the absence of costimulatory signals, or by stimulation with altered ligands. The potential association of this "anergic" phenotype and the triggering of autoimmune responses in human lupus is discussed.

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