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Review
. 2004 Apr;10(2):75-85.
doi: 10.1080/13550280490280292.

Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Sonia R Navas-Martín  1 , Susan Weiss
Affiliations
Review

Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Sonia R Navas-Martín et al. J Neurovirol. 2004 Apr.

Abstract

A novel coronavirus has been recently identified as the causative agent of the severe acute respiratory syndrome (SARS) outbreak that has accounted for more than 8000 infected people worldwide. This review will discuss current knowledge on coronavirus replication, pathogenesis, evolution, and vaccine strategies, as well as the most recent findings on SARS coronavirus.

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References

    1. Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Fleming JO, Baker SC. Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA. Virology. 1995;209:337–346. doi: 10.1006/viro.1995.1265. - DOI - PMC - PubMed
    1. Anton IM, Sune C, Meloen RH, Borras-Cuesta F, Enjuanes L. A transmissible gastroenteritis coronavirus nucleoprotein epitope elicits T helper cells that collaborate in the in vitro antibody synthesis to the three major structural viral proteins. Virology. 1995;212:746–751. doi: 10.1006/viro.1995.1535. - DOI - PMC - PubMed
    1. Ashraf H. WHO declares Beijing to be free of SARS. Lancet. 2003;361:2212–2212. doi: 10.1016/S0140-6736(03)13790-7. - DOI - PMC - PubMed
    1. Baric RS, Nelson GW, Fleming JO, Deans RJ, Keck JG, Casteel N, Stohlman SA. Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription. J Virol. 1988;62:4280–4287. - PMC - PubMed
    1. Baric RS, Sullivan E, Hensley L, Yount B, Chen W. Persistent infection promotes cross-species transmissibility of mouse hepatitis virus. J Virol. 1999;73:638–649. - PMC - PubMed

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