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. 2004 Jul 1;39(1):55-60.
doi: 10.1086/421495. Epub 2004 Jun 14.

Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City

Patricia A Bradford  1 , Simona Bratu, Carl Urban, Melissa Visalli, Noriel Mariano, David Landman, James J Rahal, Steven Brooks, Sanda Cebular, John Quale
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Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City

Patricia A Bradford et al. Clin Infect Dis. .

Abstract

Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing beta -lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta -lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States.

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