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. 2004 Jun;10(6):1138-42.
doi: 10.3201/eid1006.030575.

Predominant tuberculosis spoligotypes, Delhi, India

Urvashi Balbir Singh  1 , Naga Suresh, N Vijaya Bhanu, Jyoti Arora, Hema Pant, Sanjeev Sinha, Ram Charan Aggarwal, Sushma Singh, Jitendra Nath Pande, Christophe Sola, Nalin Rastogi, Pradeep Seth
Affiliations

Predominant tuberculosis spoligotypes, Delhi, India

Urvashi Balbir Singh et al. Emerg Infect Dis. 2004 Jun.

Abstract

One hundred five Mycobacterium tuberculosis clinical isolates from the Delhi area were typed by spoligotyping; 45 patterns were identified. Comparison with an international spoligotype database showed type 26, Delhi type (22%), type 54 (12%), and type 1, Beijing type (8%), as the most common. Eighteen spoligotypes did not match any existing database pattern.

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Figures

Figure
Figure
Dendrogram built on 105 Mycobacterium tuberculosis clinical isolates from Delhi based on spoligotyping results using the Taxotron software package (PAD Grimont, Taxolab, Institut Pasteur, Paris). This phylogenetic tree, based on the 1-Jaccard Index (8) and drawn using the unweighted pair group method with arithmetic averages (UPGMA), shows the presence of five major shared types (ST) of spoligotypes in Delhi; ST26 (Central Asian Family 1 or CAS1), ST1 (Beijing Family), ST54 (also newly designated as T1 ancestor), ST119 (X1 family) and ST11 (East African Indian 3 or EAI3 family). The strain designation appears left of the binary spoligotyping profile, and shared-type designations appear on the right of the spoligotype. Orphan patterns (unique isolates) have not been provided with a spoligotype designation on this tree.
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