Comment
doi: 10.1016/j.neuron.2004.06.007.
To learn better, keep the HAT on
Affiliations
- PMID: 15207231
- DOI: 10.1016/j.neuron.2004.06.007
Item in Clipboard
Comment
To learn better, keep the HAT on
Neuron.
.
Free article
Abstract
Long-lasting memories are known to require new transcription. Recent studies have highlighted a role for epigenetic alterations, including histone acetylation, in regulating gene expression. In this issue of Neuron, Alarcón et al. and Korzus et al. use two different mouse models of Rubinstein-Taybi syndrome to elucidate a role for the histone acetyltransferase activity of CREB binding protein (CBP) in long-term memory and plasticity.
Copyright 2004 Cell Press
Comment on
-
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.Neuron. 2004 Jun 24;42(6):947-59. doi: 10.1016/j.neuron.2004.05.021. Neuron. 2004. PMID: 15207239
-
CBP histone acetyltransferase activity is a critical component of memory consolidation.Neuron. 2004 Jun 24;42(6):961-72. doi: 10.1016/j.neuron.2004.06.002. Neuron. 2004. PMID: 15207240 Free PMC article.
Similar articles
-
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.Neuron. 2004 Jun 24;42(6):947-59. doi: 10.1016/j.neuron.2004.05.021. Neuron. 2004. PMID: 15207239
-
Rubinstein-Taybi Syndrome and Epigenetic Alterations.Adv Exp Med Biol. 2017;978:39-62. doi: 10.1007/978-3-319-53889-1_3. Adv Exp Med Biol. 2017. PMID: 28523540 Free PMC article. Review.
-
CBP histone acetyltransferase activity is a critical component of memory consolidation.Neuron. 2004 Jun 24;42(6):961-72. doi: 10.1016/j.neuron.2004.06.002. Neuron. 2004. PMID: 15207240 Free PMC article.
-
Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome.Hum Mol Genet. 2001 May 1;10(10):1071-6. doi: 10.1093/hmg/10.10.1071. Hum Mol Genet. 2001. PMID: 11331617
-
What's right with my mouse model? New insights into the molecular and cellular basis of cognition from mouse models of Rubinstein-Taybi Syndrome.Learn Mem. 2005 Mar-Apr;12(2):80-3. doi: 10.1101/lm.93505. Learn Mem. 2005. PMID: 15805305 Review. No abstract available.
Cited by
-
Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory.Int J Mol Sci. 2022 Aug 31;23(17):9916. doi: 10.3390/ijms23179916. Int J Mol Sci. 2022. PMID: 36077313 Free PMC article. Review.
-
Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease.Int J Mol Sci. 2021 Nov 13;22(22):12280. doi: 10.3390/ijms222212280. Int J Mol Sci. 2021. PMID: 34830163 Free PMC article. Review.
-
Regulation of chromatin structure in memory formation.Curr Opin Neurobiol. 2009 Jun;19(3):336-42. doi: 10.1016/j.conb.2009.05.011. Epub 2009 Jun 17. Curr Opin Neurobiol. 2009. PMID: 19539459 Free PMC article. Review.
-
A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression.Cells. 2022 May 7;11(9):1576. doi: 10.3390/cells11091576. Cells. 2022. PMID: 35563882 Free PMC article. Review.
-
Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease.Pharmacol Ther. 2013 Jul;139(1):41-50. doi: 10.1016/j.pharmthera.2013.03.010. Epub 2013 Apr 3. Pharmacol Ther. 2013. PMID: 23562602 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
