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Review
. 2004 Jul;6(8):745-51.
doi: 10.1016/j.micinf.2004.02.020.

Foxp3: a critical regulator of the development and function of regulatory T cells

Shohei Hori  1 , Shimon Sakaguchi
Affiliations
Review

Foxp3: a critical regulator of the development and function of regulatory T cells

Shohei Hori et al. Microbes Infect. 2004 Jul.

Abstract

Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.

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