Review
doi: 10.1016/j.micinf.2004.03.008.
Cytotoxic activity of the lymphocyte toxin granzyme B
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- PMID: 15207822
- DOI: 10.1016/j.micinf.2004.03.008
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Review
Cytotoxic activity of the lymphocyte toxin granzyme B
Microbes Infect.
2004 Jul.
Free article
Abstract
Cytotoxic lymphocytes protect their host from viral infection and cellular transformation by delivering a range of toxins stored within intracellular granules. One of the most potent of these toxins is the serine protease granzyme B. This review will discuss mechanisms used by granzyme B to enter target cells and the ways in which it synergizes with other granule toxins to cause cell death.
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