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Review
. 2004 Jul;6(8):752-8.
doi: 10.1016/j.micinf.2004.03.008.

Cytotoxic activity of the lymphocyte toxin granzyme B

Michelle E Wowk  1 , Joseph A Trapani
Affiliations
Free article
Review

Cytotoxic activity of the lymphocyte toxin granzyme B

Michelle E Wowk et al. Microbes Infect. 2004 Jul.
Free article

Abstract

Cytotoxic lymphocytes protect their host from viral infection and cellular transformation by delivering a range of toxins stored within intracellular granules. One of the most potent of these toxins is the serine protease granzyme B. This review will discuss mechanisms used by granzyme B to enter target cells and the ways in which it synergizes with other granule toxins to cause cell death.

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