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Review
. 2004 Jul;6(8):759-66.
doi: 10.1016/j.micinf.2004.03.007.

Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

Shengdian Wang  1 , Lieping Chen
Affiliations
Free article
Review

Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

Shengdian Wang et al. Microbes Infect. 2004 Jul.
Free article

Abstract

Co-signaling molecules in the B7-CD28 family have been intensively studied over the past decade and have brought much excitement to the field of immune regulation. The discovery of new functions for the classical pathways CD80/CD86/CD28/CTLA-4 and the identification of novel pathways of the family, including B7-H1/B7-DC/PD-1, B7-H2/ICOS, B7-H3, B7-H4 and BTLA, are greatly broadening our understanding of the control of T cell-mediated immune responses and tolerance.

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