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. 1992 Aug;3(8):700-2.

Suppression of audiogenic epileptic seizures by intracerebral injection of a CCK gene vector

L X Zhang  1 , M Wu, J S Han
Affiliations
  • PMID: 1520858

Suppression of audiogenic epileptic seizures by intracerebral injection of a CCK gene vector

L X Zhang et al. Neuroreport. 1992 Aug.

Abstract

P77PMC rat is a breed of rat with congenital audiogenic seizure (AS). AS attacks could be suppressed by cholecystokinin octapeptide (CCK-8) injected intracerebroventricularly (i.c.v.). In the present study we made i.c.v. injection of plasmid pSV2-beta Gal or pSV2-CCK encapsulated with lipofectin. Expression of pSV2-beta Gal in brain occurred from d 1 to d 14, with maximal expression at d 3 and d 4. After i.c.v. injection of pSV2-CCK plasmid, the AS of the P77PMC rats was markedly reduced, which was most obvious at d 3 and d 4. The time course of the AS repression was almost identical with that of pSV2-beta Gal expression. The results suggest that the repression of the AS in P77PMC rats is accounted for by the expression of foreign CCK gene in brain tissue.

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