Comparative Study
doi: 10.1038/nn1270.
Epub 2004 Jun 20.
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
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- PMID: 15208630
- DOI: 10.1038/nn1270
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Comparative Study
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Nat Neurosci.
2004 Jul.
Abstract
The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.
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