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Comparative Study
. 2004 Jul;7(7):695-6.
doi: 10.1038/nn1270. Epub 2004 Jun 20.

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

Laurent Groc  1 , Martin Heine, Laurent Cognet, Kieran Brickley, F Anne Stephenson, Brahim Lounis, Daniel Choquet
Affiliations
Comparative Study

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

Laurent Groc et al. Nat Neurosci. 2004 Jul.

Abstract

The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.

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