Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992;29(1):41-5.
doi: 10.1007/BF00572829.

Alginate coating of islets of Langerhans: in vitro studies on a new method for microencapsulation for immuno-isolated transplantation

T Zekorn  1 , U Siebers, A Horcher, R Schnettler, U Zimmermann, R G Bretzel, K Federlin
Affiliations

Alginate coating of islets of Langerhans: in vitro studies on a new method for microencapsulation for immuno-isolated transplantation

T Zekorn et al. Acta Diabetol. 1992.

Abstract

Immuno-isolated transplantation offers the attractive prospect of being able to transplant xenogeneic islets without immunosuppression. This study introduces a completely new method of coating single islets using a homogeneous alginate membrane approximately 10 microns thick. During glucose challenge (perifusion and static incubation) encapsulated islets show the same pattern and quantity of insulin release as non-encapsulated controls. This encapsulation method markedly reduces the amount of transplanted material by reducing the size of the capsule. It is suggested that encapsulated islets may be transplanted into sites such as the renal capsule or omentum or even by intraportal injection into the liver.

PubMed Disclaimer

References

    1. Lancet. 1990 Aug 18;336(8712):402-5 - PubMed
    1. Horm Metab Res. 1991 Jun;23(6):302-3 - PubMed
    1. Science. 1980 Nov 21;210(4472):908-10 - PubMed
    1. Diabetes. 1990 Apr;39(4):515-8 - PubMed
    1. Transplantation. 1991 Mar;51(3):651-5 - PubMed

Publication types

LinkOut - more resources