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. 2004;8(2):141-5.
doi: 10.1023/b:modi.0000025613.35304.25.

A reexamination of Biginelli-like multicomponent condensation reaction: one-pot regioselective synthesis of spiro heterobicyclic rings

Ahmad Shaabani  1 , Ayoob Bazgir, Hamid Reza Bijanzadeh
Affiliations

A reexamination of Biginelli-like multicomponent condensation reaction: one-pot regioselective synthesis of spiro heterobicyclic rings

Ahmad Shaabani et al. Mol Divers. 2004.

Abstract

A pseudo four-component reaction is described, leading to the efficient regioselective synthesis of sigma symmetric spiro heterobicyclic rings using aldehydes and urea in the presence of cyclic beta-diester or beta-diamides such as Meldrum's acid or barbituric acid derivatives. The reaction needs no added catalyst and proceeds solvent-free conditions at 80 degrees C.

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