Polyethyleneglycols and immunocamouflage of the cells tissues and organs for transplantation

Abstract

In allogenic transplant the immediate immune response is due to the recipient T cell recognition of non-self molecules presented on graft resident donor antigen presenting cells. An alternative to the transplantation tolerance paradigm is based on the development of strategies which distort alloimmune recognition of the graft by antigen reactive cells of the recipient. Immunocamouflage relies on the modification of the cell membrane surface with non-immunogenic molecules creating a barrier that prevents the recognition of antigenic sites by cells and antibodies of the recipient. Polymers can spontaneously bind to cell and tissues surfaces and sterically stabilize the underlying surface from interactions with other components in the surrounding. They can be adsorbed or chemically grafted to surfaces. Polyethylene glycol (PEG) seems to be the more effective at sterically stabilizing underlying surfaces. The outstanding protection provided by this polymer has been attributed to its molecular properties, such as its low interfacial energy, its conformation, hydrophilicity and high flexibility. The main advantage of immunocamouflage, is that it directly modify the inherent immunogenicity of the donor tissue itself, using means that are strictly physicochemical in nature and do not rely on the details of activation pathways, leaving fully competent, the immune system of the recipient.