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. 2004 Jun 22;62(12):2323-5.
doi: 10.1212/wnl.62.12.2323.

Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes

J M Partridge  1 , S J M Weatherby, J A Woolmore, D J Highland, A A Fryer, C L A Mann, M D Boggild, W E R Ollier, R C Strange, C P Hawkins
Affiliations

Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes

J M Partridge et al. Neurology. .

Abstract

Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.

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