Case Reports
doi: 10.1111/j.1469-0691.2004.00890.x.
High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany
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- PMID: 15214881
- DOI: 10.1111/j.1469-0691.2004.00890.x
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Case Reports
High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany
Clin Microbiol Infect.
2004 Jul.
Free article
Abstract
An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC > or = 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.
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