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Review
. 2004 Jun 23:5:17.
doi: 10.1186/1471-2156-5-17.

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

Debbie A Lawlor  1 , Ian N M Day, Tom R Gaunt, Lesley J Hinks, Patricia J Briggs, Matthew Kiessling, Nick Timpson, George Davey Smith, Shah Ebrahim
Affiliations
Review

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

Debbie A Lawlor et al. BMC Genet. .

Abstract

Background: There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included predominantly men and the association in women is unclear. Since lipid levels vary between the sexes the antioxidant effect of PON1 and any genes associated with it may also vary by sex. We have examined the association of the PON1 Q192R polymorphism with CHD in a large cohort of British women and combined the results from our cohort study with those from all other published studies.

Results: The distribution of genotypes was the same among women with CHD and those without disease. The odds ratio (95% confidence interval) of having CHD comparing those with either the QR or RR genotype to those with QQ genotype (dominant model of association) was 1.03 (0.89, 1.21) and the per allele odds ratio was 0.98 (0.95, 1.01). In a meta-analysis of this and 38 other published studies (10,738 cases and 17,068 controls) the pooled odds ratio for the dominant effect was 1.14 (1.08, 1.20) and for the per allele effect was 1.10 (1.06, 1.13). There was evidence of small study bias in the meta-analyses and the dominant effect among those studies with 500 or more cases was 1.05 (0.96, 1.15). Ethnicity and reporting of whether the genotyping was done blind to the participants clinical status also contributed to heterogeneity between studies, but there was no difference in effect between studies with 50% or more women compared to those with fewer women and no difference between studies of healthy populations compared to those at high risk (with diabetes, renal disease of familial hypercholesterolaemia).

Conclusion: There is no robust evidence that the PON1 Q192R polymorphism is associated with CHD risk in Caucasian women or men.

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Figures

Figure 1
Figure 1
Meta-analysis of association of PON1 Q192R polymorphism with coronary heart disease (dominant model: QR or RR genotype versus QQ genotype). Based on a total of 10738 cases and 17068 controls from 39 studies.
Figure 2
Figure 2
Pooled estimates of the association of PON1 Q192R polymorphism with coronary heart disease (dominant model: QR or RR genotype versus QQ genotype) by study characteristics
See this image and copyright information in PMC

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References

    1. Ellsworth DL, Sholinsky P, Jaquish C, Fabsitz RR, Manolio TA. Coronary heart disease. At the interface of molecular genetics and preventive medicine. American Journal of Preventive Medicine. 1999;16:122–133. doi: 10.1016/S0749-3797(98)00138-X. - DOI - PubMed
    1. Parthasarathy S, Barnett J, Fong LG. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochimica et Biophysica Acta. 1990;1044:275–283. doi: 10.1016/0005-2760(90)90314-N. - DOI - PubMed
    1. Mackness MI, Durrington PN, Mackness B. How high-density lipoprotein protects against the effects of lipid peroxidation. Current Opinion in Lipidology. 2000;11:383–388. doi: 10.1097/00041433-200008000-00007. - DOI - PubMed
    1. Mackness MI, Abbott C, Arrol S, Durrington PN. The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation. Biochemical Journal. 1993;294:829–834. - PMC - PubMed
    1. Durrington PN, Mackness B, Mackness MI. Paraoxonase and atherosclerosis. Arteriosclerosis, Thrombosis & Vascular Biology. 2001;21:473–480. - PubMed

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