Review
Etiology of pituitary acromegaly
Affiliations
- PMID: 1521511
Item in Clipboard
Review
Etiology of pituitary acromegaly
Endocrinol Metab Clin North Am.
1992 Sep.
Abstract
Pituitary tumors secreting growth hormone are clonal neoplasms that may arise following a somatic mutation within the somatotroph cell. Promotion of tumor growth also appears to be regulated by hypothalamic growth hormone-releasing hormone, which exerts a trophic action on the pituitary cell. Unraveling the mechanisms of pituitary tumorigenesis will facilitate the application of novel therapeutic techniques, genetic screening, and follow-up of tumor responses.
Similar articles
-
Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors.Chin Med J (Engl). 1998 Oct;111(10):891-4. Chin Med J (Engl). 1998. PMID: 11189233
-
Overgrowth. Hormonal Causes.Clin Pediatr (Phila). 1996 Nov;35(11):579-90. Clin Pediatr (Phila). 1996. PMID: 8953133 Review. No abstract available.
-
[Acromegaly. Physiopathological aspects and description of a clinical case].Minerva Med. 1986 Mar 17;77(11):395-401. Minerva Med. 1986. PMID: 3085021 Italian.
-
Growth hormone-secreting pituitary adenoma of mixed cell type: a histological, ultrastructural and immunocytochemical study.Clin Neuropathol. 1986 Jan-Feb;5(1):28-33. Clin Neuropathol. 1986. PMID: 3948451
-
Pituitary neoplasia.Endocrinol Metab Clin North Am. 1994 Mar;23(1):81-92. Endocrinol Metab Clin North Am. 1994. PMID: 7913031 Review.
Cited by
-
Neuroendocrine tumors secreting growth hormone-releasing hormone: Pathophysiological and clinical aspects.Pituitary. 2006;9(3):221-9. doi: 10.1007/s11102-006-0267-0. Pituitary. 2006. PMID: 17036195 Review.
-
Pituitary tumors. Current concepts in diagnosis and management.West J Med. 1995 Apr;162(4):340-52. West J Med. 1995. PMID: 7747500 Free PMC article. Review.
-
Significance of growth hormone-releasing hormone receptor mRNA in non-neoplastic pituitary and pituitary adenomas: a study by RT-PCR and in situ hybridization.J Neurooncol. 1999 Feb;41(3):197-204. doi: 10.1023/a:1006151001536. J Neurooncol. 1999. PMID: 10359139
-
Combined sellar gangliocytoma and pituitary adenoma in acromegaly or Cushing's disease. A report of 3 cases.Virchows Arch. 1994;425(1):93-9. doi: 10.1007/BF00193956. Virchows Arch. 1994. PMID: 7921420 Review.
-
Overexpression of the growth-hormone-releasing hormone gene in acromegaly-associated pituitary tumors. An event associated with neoplastic progression and aggressive behavior.Am J Pathol. 1997 Sep;151(3):769-84. Am J Pathol. 1997. PMID: 9284826 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical