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Comparative Study
. 2004 Jul;48(7):2719-23.
doi: 10.1128/AAC.48.7.2719-2723.2004.

In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci

Vanthida Huang  1 , William J Brown, Michael J Rybak
Affiliations
Comparative Study

In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci

Vanthida Huang et al. Antimicrob Agents Chemother. 2004 Jul.

Abstract

We examined the activity of CB-181963, a novel cephalosporin, against methicillin-resistant Staphylococcus aureus (MRSA) (n = 200), methicillin-susceptible S. aureus (MSSA) (n = 50), glycopeptide-intermediate Staphylococcus species (GISS) (n = 47), and VRSA (n = 2) isolates. CB-181963 exhibited MIC profiles similar to those of linezolid against MRSA and GISS; however, activity against MSSA was similar to that of vancomycin. Time-kill study results of investigations of activity against MRSA, MSSA, and GISS at 24 h were as follows: CB-181963 activity = vancomycin activity > linezolid activity (P < 0.001); CB-181963 = quinupristin-dalfopristin = vancomycin > linezolid (P < 0.05); CB-181963 > linezolid (P = 0.003); and CB-181963 = quinupristin-dalfopristin = vancomycin. CB-181963 may provide an alternative treatment for multidrug-resistant staphylococci.

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Figures

FIG. 1.
FIG. 1.
CB-181963 chemical structure.
FIG. 2.
FIG. 2.
Time-kill experiments at four times the MIC for a combination of four selected clinical MRSA strains (A), four times the MIC for four selected clinical MSSA strains (B), two times the MIC for a combination of four selected clinical GISS strains (including three S. aureus and one S. epidermidis strains; the drug MIC for all strains was 8 μg/ml) (C), and two times the MIC for clinical strains of VRSA-MI and VRSA-PA (D and E). Results represent means ± standard deviations. GC, growth control; C, CB-181963; L, linezolid; Q-D, quinupristin-dalfopristin; V, vancomycin.
FIG. 2.
FIG. 2.
Time-kill experiments at four times the MIC for a combination of four selected clinical MRSA strains (A), four times the MIC for four selected clinical MSSA strains (B), two times the MIC for a combination of four selected clinical GISS strains (including three S. aureus and one S. epidermidis strains; the drug MIC for all strains was 8 μg/ml) (C), and two times the MIC for clinical strains of VRSA-MI and VRSA-PA (D and E). Results represent means ± standard deviations. GC, growth control; C, CB-181963; L, linezolid; Q-D, quinupristin-dalfopristin; V, vancomycin.
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