Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jul;48(7):2730-2.
doi: 10.1128/AAC.48.7.2730-2732.2004.

Micafungin enhances neutrophil fungicidal functions against Candida pseudohyphae

Cristina Gil-Lamaignere  1 , Stefanie Salvenmoser, Regina Hess, Frank-Michael C Müller
Affiliations

Micafungin enhances neutrophil fungicidal functions against Candida pseudohyphae

Cristina Gil-Lamaignere et al. Antimicrob Agents Chemother. 2004 Jul.

Abstract

We evaluated the effect of the combination of micafungin and polymorphonuclear leukocytes (PMN) against hyphae of Candida albicans and Candida dubliniensis. Micafungin enhanced the PMN oxidative burst dose dependently. The combination was synergistic (C. albicans) or additive (C. dubliniensis); when PMN were pretreated with granulocyte-macrophage colony-stimulating factor, the combination was more effective.

PubMed Disclaimer

References

    1. Abu, J. L., R. Haidar, F. Bitar, S. Mroueh, S. Akel, N. Nuwayri-Salti, and G. S. Dbaibo. 2000. Aspergillus vertebral osteomyelitis in a child with a primary monocyte killing defect: response to GM-CSF therapy. J. Infect. 41:97-100. - PubMed
    1. Gaviria, J. M., J. A. van Burik, D. C. Dale, R. K. Root, and W. C. Liles. 1999. Comparison of interferon-gamma, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor for priming leukocyte-mediated hyphal damage of opportunistic fungal pathogens. J. Infect. Dis. 179:1038-1041. - PubMed
    1. Gil-Lamaignere, C., E. Roilides, C. A. Lyman, M. Simitsopoulou, T. Stergiopoulou, A. Maloukou, and T. J. Walsh. 2003. Human phagocytic cell responses to Scedosporium apiospermum (Pseudallescheria boydii): variable susceptibility to oxidative injury. Infect. Immun. 71:6472-6478. - PMC - PubMed
    1. Gil-Lamaignere, C., E. Roilides, J. Mosquera, A. Maloukou, and T. J. Walsh. 2002. Antifungal triazoles and polymorphonuclear leukocytes synergize to cause increased hyphal damage to Scedosporium prolificans and Scedosporium apiospermum. Antimicrob. Agents Chemother. 46:2234-2237. - PMC - PubMed
    1. Gurer, U. S., A. Cevikbas, C. Johansson, K. Derici, and T. Yardimci. 1999. Effect of fluconazole on human polymorphonuclear leucocyte functions ex vivo against Candida albicans. Chemotherapy 45:277-283. - PubMed

Publication types

LinkOut - more resources