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. 2004 Jul 1;32(Web Server issue):W346-9.
doi: 10.1093/nar/gkh482.

RECON: a program for prediction of nucleosome formation potential

Victor G Levitsky  1
Affiliations

RECON: a program for prediction of nucleosome formation potential

Victor G Levitsky. Nucleic Acids Res. .

Abstract

The program RECON has been designed for constructing profiles of nucleosome potential, characterizing the probability of nucleosome formation along DNA sequences. The program used for recognition of nucleosome formation sites in genomic DNA sequences. It was developed using discriminant analysis based on a genetic algorithm method utilizing statistics for dinucleotide location within local regions of nucleosome formation sites. The program RECON is available at http://wwwmgs.bionet.nsc.ru/mgs/programs/recon/.

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Figures

Figure 1
Figure 1
Interface of the program RECON.
Figure 2
Figure 2
Representation of the results of an analysis in (A) numerical format and (B) graphical mode when a region of the sequence does not meet the condition on dinucleotide composition (Equation 7).
Figure 3
Figure 3
Representation of the results of an analysis in graphical mode using the example of the mouse GM–CSF gene with the option ‘Standardization by dispersion’ switched (A) off and (B) on. Arrows indicate positions of the nucleosome centers.
Figure 4
Figure 4
Nucleosome formation potential ϕ(X) profiles for the Homo sapiens alpha-fetoprotein gene. The ovals denote nucleosome formation site regions (16). The intron and exon locations are shown below.
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References

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