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. 2004 Jul 15;190(2):373-8.
doi: 10.1086/421524. Epub 2004 Jun 18.

Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults

Edward E Walsh  1 , Ann R Falsey
Affiliations

Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults

Edward E Walsh et al. J Infect Dis. .

Abstract

Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV)-infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.

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