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. 1992 May;35(5):419-24.
doi: 10.1007/BF02342437.

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

T Awata  1 , T Kuzuya, A Matsuda, Y Iwamoto, Y Kanazawa
Affiliations

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

T Awata et al. Diabetologia. 1992 May.

Erratum in

  • Diabetologia 1992 Sep;35(9):906

Abstract

Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele. We analysed the DRB1, DQA1 and DQB1 genes of 99 Japanese patients and 86 control subjects with polymerase chain reaction and sequence-specific oligonucleotide hybridization. We found that (1) the DQA1*0301 allele was significantly increased in Type 1 diabetic patients (RR7.8, pc less than 0.0001); (2) the DRB1*0405 (Dw15) allele, which is a subtype of DR4 haplotype, was significantly increased in DR4-positive patients (RR 12.0, pc less than 0.001); and (3) although the DRw8-DQw8 haplotype was positively associated with Type 1 diabetes, the DRB1*0406-DQw8 haplotype was decreased in the diabetic patients. These data indicate that DRB1 and DQA1 genes also confer susceptibility to Type 1 diabetes in Japanese.

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References

    1. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1094-8 - PubMed
    1. Diabetes. 1990 Oct;39(10):1153-7 - PubMed
    1. Diabetes. 1990 Feb;39(2):266-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8111-5 - PubMed
    1. Nature. 1988 Apr 28;332(6167):845-50 - PubMed

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