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. 2004 Jun;67(6):986-9.
doi: 10.1021/np040058h.

Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest

Shugeng Cao  1 , Rebecca Clare Guza, James S Miller, Rabodo Andriantsiferana, Vincent E Rasamison, David G I Kingston
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Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest

Shugeng Cao et al. J Nat Prod. 2004 Jun.

Abstract

Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids, moronic acid (6), ursolic acid, and oleanolic acid; and two known flavonoids, 4',5-dihydroxy-7-methoxyflavone and 4',5-dihydroxy-3',7-dimethoxyflavone. The structures of the new compounds 1-5 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 3 showed significant cytotoxic activity in the A2780 assay, with an IC50 value of 0.7 microg/mL.

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