Does the act of surgery provoke activation of "latent" metastases in early breast cancer?
- PMID: 15217487
- PMCID: PMC468671
- DOI: 10.1186/bcr902
Does the act of surgery provoke activation of "latent" metastases in early breast cancer?
Abstract
This paper is written in support of the challenging article by Retsky and colleagues in this issue of Breast Cancer Research, and develops on the idea that the act of surgery can provoke the outgrowth of dormant micrometastases, which often leads to the failure of screening to deliver its promise. The therapeutic consequence of this idea involves the use of antiangiogenic drugs before surgery.
Comment on
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Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients.Breast Cancer Res. 2004;6(4):R372-4. doi: 10.1186/bcr804. Epub 2004 May 14. Breast Cancer Res. 2004. PMID: 15217504 Free PMC article.
References
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- Retsky M, Bonadonna G, Demicheli R, Folkman J, Hrushesky W, Valagussa P. Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients. Breast Cancer Res. 2004;6:R372–R374. doi: 10.1186/bcr804. - DOI - PMC - PubMed
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- Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, Rijn Mv M, Botstein D, Brown PO. Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumours and wounds. PLoS Biol. 2004;2:E7. doi: 10.1371/journal.pbio.0020007. - DOI - PMC - PubMed
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