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. 1992 Sep;90(3):1105-9.
doi: 10.1172/JCI115927.

Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H)

A E Gharavi  1 , L R Sammaritano, J Wen, K B Elkon
Affiliations

Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H)

A E Gharavi et al. J Clin Invest. 1992 Sep.

Abstract

A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies.

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